The Man-Thing was once the brilliant biochemist Dr. Ted Sallis. While working for S.H.I.E.L.D. to replicate the Super Soldier Serum, Dr. Sallis was forced to flee due to an A.I.M. plot to steal his work. Injecting himself with the only remaining sample of his serum before crashing his car into the swamp while on the run. Rather than dying from that crash, he was reformed into a creature made of the swamp itself, The Man-Thing!